Functionalization of MWNT-COOH by one-step reaction with (3-oxoindolin-2-ylidene) urea and in vitro antitumor study on gastric cancer

AIM In this study, we was tried to prepare a nano compound with a new way in functionalization as anti gastric cancer candidate. BACKGROUND Functionalization of nanotubes is a useful route for modification of their biologic properties. (3-oxoindolin-2-ylidene) urea is a chemical compound that made of isatin and urea that can be useful in cancer study. PATIENTS AND METHODS MWNT-COOH was functionalized by this compound with one-step reaction that is a new class in modification. Product has been investigated by FT-IR, Raman and SEM. Anti cancer investigation with human gastric cells and MTT assay test for measurement of viable cell numbers were also performed. RESULTS The two bands at around 2800-2900 cm(-1) which are seen in functionalized product are attributed to the CH stretching of MWNT-COOH defects. CONCLUSION Cellular results demonstrated that the functionalized nano-tube is a more toxic agent compared to other samples for cancer cells and can be used as a candidate material for chemotherapy.